Drug tolerance is basically the body's ability to
adapt to the presence of a drug. Pharmacology
refers to the actions of drugs on mechanisms in the body. The effect of a drug
is proportional to the concentration of that drug at its site of action.
Drug abuse refers to the use, usually by
self-administration, of any drug in a manner that deviates from the approved
medical or social patterns within a given culture. This definition is largely a
social one. For any given drug, there is a large variation in what is
considered abuse, not only from culture to culture, but also from one
generation to another. Alcohol is a good example of this, as is the use of
cigarette tobacco.
The magnitude of the body's response to a particular
drug depends on two factors:
- Concentration of the drug at its site of action
- Sensitivity of the target site to the drug
The sensitivity of the target cells is governed by
genetic factors and adaptive changes by the body. Adaptive changes occur in
response to the repeated exposure to a particular drug. The result is usually a
loss of sensitivity to the drug. This decreased response is called tolerance
Tolerance may be defined as a state of progressively
decreased responsiveness to a drug as a result of which a larger dose of the
drug is needed to achieve the effect originally obtained by a smaller dose.
Apcalis jelly is one of the most popular erectile
dysfunction and premature ejaculation treatment pills manufactured by Ajanta
Pharma. Apcalis jelly works similar to Cialis as it consist
the same active ingredient, but has more different types (flavours). Apcalis
oral jelly consist of Tadalafil active ingridient but produced with a wide
selection of original flafours. In most cases though, it is best when taken 45
minutes prior to having sex. Apcalis Oral Jelly will be in the body for up to 4
hours. Apcalis Oral Jelly is a used to provide an erection when sexually
stimulated. So, usage of the drug is restricted if you have a history of heart
problems like arrhythmic disorders, heart attack or stroke.
If you notice any symptoms like, chest, shoulder,
neck, or jaw pain; numbness of an arm or leg; severe dizziness, headache,
nausea, stomach pain, or vomiting; fainting; or vision changes, while indulging
in sexual activity or any other vigorous exercise, then stop doing it
immediately. Seek emergency medical care for it might be signs of a heart
attack.
Apcalis Oral Jelly is known to react adversely when
combined with certain medications. The reactions are normally mild in nature
but can be severe at times.
These medications include:
Nitrates in any form (Ointments, patches, pills). This
includes any and all medications containing nitrates including Nitrostat,
Nitrolingual, Nitro-Dur, Nitro-Bid, Minitran, Deponit, Transderm-Nitro,
Dilatrate-SR, Isordil, Sorbitrate, sosorbide mononitrate (Imdur, ISMO,
Monoket).
Recreational pills called poppers.
Bosentan (Tracleer);
A blood thinner such as warfarin (Coumadin);
Cimetidine (Tagamet, Tagamet HB);
An antibiotic such as erythromycin (E-Mycin, Eryc,
Ery-Tab) or clarithromycin (Biaxin);
Doxazosin (Cardura), prazosin (Minipress), Terazosin
(Hytrin);
HIV medicines such as amprenavir (Agenerase),
tipranavir (Aptivus), darunavir (Prezista);
An antifungal medication such as itraconazole
(Sporanox) or ketoconazole (Nizoral);
Carbamazepine (Tegretol), phenobarbital (Luminal), or
phenytoin (Dilantin); or
Rifampin (Rifadin, Rimactane) or rifabutin
(Mycobutin).
