Drug tolerance

Drug tolerance is basically the body's ability to adapt to the presence of a drug. Pharmacology refers to the actions of drugs on mechanisms in the body. The effect of a drug is proportional to the concentration of that drug at its site of action.

Drug abuse refers to the use, usually by self-administration, of any drug in a manner that deviates from the approved medical or social patterns within a given culture. This definition is largely a social one. For any given drug, there is a large variation in what is considered abuse, not only from culture to culture, but also from one generation to another. Alcohol is a good example of this, as is the use of cigarette tobacco.

The magnitude of the body's response to a particular drug depends on two factors:

• Concentration of the drug at its site of action
• Sensitivity of the target site to the drug

The sensitivity of the target cells is governed by genetic factors and adaptive changes by the body. Adaptive changes occur in response to the repeated exposure to a particular drug. The result is usually a loss of sensitivity to the drug. This decreased response is called tolerance

Tolerance may be defined as a state of progressively decreased responsiveness to a drug as a result of which a larger dose of the drug is needed to achieve the effect originally obtained by a smaller dose.

Apcalis jelly is one of the most popular erectile dysfunction and premature ejaculation treatment pills manufactured by Ajanta Pharma. Apcalis jelly works similar to Cialis as it consist the same active ingredient, but has more different types (flavours). Apcalis oral jelly consist of Tadalafil active ingridient but produced with a wide selection of original flafours. In most cases though, it is best when taken 45 minutes prior to having sex. Apcalis Oral Jelly will be in the body for up to 4 hours. Apcalis Oral Jelly is a used to provide an erection when sexually stimulated. So, usage of the drug is restricted if you have a history of heart problems like arrhythmic disorders, heart attack or stroke.

If you notice any symptoms like, chest, shoulder, neck, or jaw pain; numbness of an arm or leg; severe dizziness, headache, nausea, stomach pain, or vomiting; fainting; or vision changes, while indulging in sexual activity or any other vigorous exercise, then stop doing it immediately. Seek emergency medical care for it might be signs of a heart attack.

Apcalis Oral Jelly is known to react adversely when combined with certain medications. The reactions are normally mild in nature but can be severe at times.

These medications include:

Nitrates in any form (Ointments, patches, pills). This includes any and all medications containing nitrates including Nitrostat, Nitrolingual, Nitro-Dur, Nitro-Bid, Minitran, Deponit, Transderm-Nitro, Dilatrate-SR, Isordil, Sorbitrate, sosorbide mononitrate (Imdur, ISMO, Monoket).

Recreational pills called poppers.

Bosentan (Tracleer);

A blood thinner such as warfarin (Coumadin);

Cimetidine (Tagamet, Tagamet HB);

An antibiotic such as erythromycin (E-Mycin, Eryc, Ery-Tab) or clarithromycin (Biaxin);

Doxazosin (Cardura), prazosin (Minipress), Terazosin (Hytrin);

HIV medicines such as amprenavir (Agenerase), tipranavir (Aptivus), darunavir (Prezista);

An antifungal medication such as itraconazole (Sporanox) or ketoconazole (Nizoral);

Carbamazepine (Tegretol), phenobarbital (Luminal), or phenytoin (Dilantin); or

Rifampin (Rifadin, Rimactane) or rifabutin (Mycobutin).

Viagra Super Active

Viagra Super Active is an improved formula of Sildenafil Citrate which gives men an opportunity to increase their sexual activity and get new sensations during the sexual activity. A unique peculiarity of this drug is that it is released in the form of the fast-dissolving capsules, and therefore you do not have to wait for the beginning of the action.

Viagra Super Active is a phosphodiesterase type 5 (PDE5) inhibitor. It works by helping to increase blood flow into the penis during sexual stimulation. This helps you to achieve and maintain an erection.

Viagra Super Active will dissolve almost immediately once in your system, allowing the active ingredient to be absorbed into the blood stream faster than other varieties of Viagra. This means you'll have a better turn-around, so to speak, in between ingestion and intercourse. That being said, it's still recommended that the pill be taken at least an hour prior to sexual activity.

Take Viagra Super Active by mouth with or without food about 1 hour before sexual activity. It may not work as quickly if you take it with a high-fat meal.

Viagra Super Active can help you have an erection when sexual stimulation occurs. An erection will not occur just by taking a pill. Viagra Super Active may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Patients with heart problems who take Viagra Super Active capsules may be at increased risk for heart-related side effects, including heart attack or stroke. Symptoms of a heart attack may include chest, shoulder, neck, or jaw pain; numbness of an arm or leg; severe dizziness, headache, nausea, stomach pain, or vomiting; fainting; or vision changes. Symptoms of a stroke may include confusion, vision or speech changes, one-sided weakness, or fainting. Contact your doctor or seek medical attention right away if you experience these symptoms. Viagra Super Active is not recommended for use in children younger 18 years.

Check with your doctor if any of these most common side effects persist or become bothersome: diarrhea; dizziness; flushing; headache; heartburn; stuffy nose; upset stomach.

Seek medical attention right away if any of these severe side effects occur: severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fainting; fast or irregular heartbeat; memory loss; numbness of an arm or leg; one-sided weakness; painful or prolonged erection; ringing in the ears; seizure; severe or persistent dizziness; severe or persistent vision changes; sudden decrease or loss of hearing; sudden decrease or loss of vision in one or both eyes.